Primary aldosteronism: considerations about the evaluation of the aldosterone to renin ratio during canrenone treatment

@article{Armanini2021PrimaryAC,
  title={Primary aldosteronism: considerations about the evaluation of the aldosterone to renin ratio during canrenone treatment},
  author={D. Armanini and C. Sabbadin and M. Boscaro},
  journal={Journal of Endocrinological Investigation},
  year={2021},
  volume={44},
  pages={2009 - 2010}
}
Recently Rossi and coll. have published an interesting study on the measurement of the aldosterone to renin ratio (ARR) during treatment with canrenone, for the diagnosis of primary aldosteronism (PA) [1]. This approach to the diagnosis of PA avoids the risk related to the withdrawal of antihypertensive treatment and to hypokalemia. The authors conclude that treatment with canrenone at doses that effectively controlled hypokalemia and blood pressure values did not preclude the diagnosis in PA… Expand
1 Citations
Mineralocorticoid receptor antagonist effect on aldosterone to renin ratio in patients with primary aldosteronism.
TLDR
It is demonstrated that canrenone exerted a deep impact on the diagnostic accuracy of the screening test for primary aldosteronism: the rate of false negative tests raised to 16.7% after 2 weeks, 8 weeks, 2-6 months and 7-12 months of mineralocorticoid receptor antagonist treatment, respectively. Expand

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