Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner

@article{Komatsu2011PrimaryAA,
  title={Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner},
  author={Tomoko Komatsu and Kunitoshi Uchida and Fumitaka Fujita and Yiming Zhou and Makoto Tominaga},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2011},
  volume={463},
  pages={549-559}
}
Transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable non-selective cation channel that is mainly expressed in primary nociceptive neurons. TRPA1 is activated by a variety of noxious stimuli, including cold temperatures, pungent compounds such as mustard oil and cinnamaldehyde, and intracellular alkalization. Here, we show that primary alcohols, which have been reported to cause skin, eye or nasal irritation, activate human TRPA1 (hTRPA1). We measured intracellular Ca2+ changes… CONTINUE READING

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