Primary age-related tauopathy (PART): a common pathology associated with human aging

@article{Crary2014PrimaryAT,
  title={Primary age-related tauopathy (PART): a common pathology associated with human aging},
  author={John Fonda Crary and John Q. Trojanowski and Julie A Schneider and Jose F Abisambra and Erin Lynn Abner and Irina Alafuzoff and Steven E Arnold and Johannes Attems and Thomas Gerald Beach and Eileen Bigio and Nigel J. Cairns and Dennis W. Dickson and Marla Gearing and Lea Tenenholz Grinberg and Patrick R. Hof and Bradley T. Hyman and Kurt A. Jellinger and Gregory A. Jicha and Gabor G Kovacs and David S. Knopman and Julia K Kofler and Walter Kukull and Ian R Mackenzie and Eliezer Masliah and Ann Mckee and Thomas J. Montine and Melissa E. Murray and Janna H. Neltner and Ismael Santa-Mar{\'i}a and William W. Seeley and Alberto Serrano-Pozo and Michael L Shelanski and Thor D. Stein and Masaki Takao and Dietmar Rudolf Thal and Jonathan B. Toledo and Juan C Troncoso and Jean Paul G. Vonsattel and Charles L. White 3rd and Thomas Wisniewski and Randall L. Woltjer and Masahito Yamada and Peter T. Nelson},
  journal={Acta Neuropathologica},
  year={2014},
  volume={128},
  pages={755-766}
}
We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer’s disease (AD), in the absence of amyloid (Aβ) plaques. For these “NFT+/Aβ−” brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial… CONTINUE READING
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