Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia

@article{Dina2005PrimaryAS,
  title={Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia},
  author={Olayinka A Dina and Tim Hucho and J Yeh and Misbah Malik-Hall and Jon D Levine},
  journal={Pain},
  year={2005},
  volume={115},
  pages={191-203}
}
We recently reported that hyperalgesia induced by the inflammatory mediator prostaglandin E(2) (PGE(2)) requires intact alpha1, alpha3 and beta1 integrin subunit function, whereas epinephrine-induced hyperalgesia depends on alpha5 and beta1. PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase… CONTINUE READING

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