Primary adult human bone cells do not respond to tissue (continuum) level strains.

Abstract

Bone adapts to its mechanical environment, and, since the late 1800s, investigators have presumed that this adaptation relates to strain magnitude. Indeed, overwhelming evidence supports the view that either strain or some strain-related quantity stimulates bone adaptation or remodeling. Virtually all investigators, implicitly or explicitly, assume that the… (More)

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@article{Brand2001PrimaryAH, title={Primary adult human bone cells do not respond to tissue (continuum) level strains.}, author={Ronaldt Brand and Clark M. Stanford and Daniel P. Nicolella}, journal={Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association}, year={2001}, volume={6 3}, pages={295-301} }