Primary Structure of the Human Platelet Serotonin 5‐HT2A Receptor: Identity with Frontal Cortex Serotonin 5‐HT2A Receptor

  title={Primary Structure of the Human Platelet Serotonin 5‐HT2A Receptor: Identity with Frontal Cortex Serotonin 5‐HT2A Receptor},
  author={Edwin H. Cook and Kathlyn E. Fletcher and Mark S. Wainwright and N. Marks and S Y Yan and Bennett L. Leventhal},
  journal={Journal of Neurochemistry},
Abstract: Previous radioligand binding studies have demonstrated human platelet serotonin2A (5‐HT2A) receptor binding sites. Pharmacological similarities between platelet and frontal cortex 5‐HT2A receptor binding parameters have been demonstrated. However, it is not clear whether the platelet 5‐HT2A receptor primary structure is identical to that of the brain receptor. Three overlapping cDNAs were obtained to span completely the coding region of the 5‐HT2A receptor. These clones were sequenced… 

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Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.

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Comparison of [125I]Iodolysergic Acid Diethylamide Binding in Human Frontal Cortex and Platelet Tissue

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