Primary Progressive Aphasia: Clinical, Imaging, and Neuropathological Findings

  title={Primary Progressive Aphasia: Clinical, Imaging, and Neuropathological Findings},
  author={Gediminas Gliebus},
  journal={American Journal of Alzheimer's Disease and Other Dementias{\textregistered}},
  pages={125 - 127}
  • G. Gliebus
  • Published 1 February 2010
  • Psychology, Medicine
  • American Journal of Alzheimer's Disease and Other Dementias®
Primary Progressive Aphasia (PPA) is a neurodegenerative disorder initially presenting with progressive language imapirment. This article provides a clinically oriented review of PPA. Different clinical presentations and imaging findings of 3 subtypes, agrammatic, semantic and logopenic, are presented. Underlying neuropathology, medical and social management aspects of these patients are reviewed. 

18 F-FDG PET / CT findings in a case of a semantic variant of primary progressive aphasia

This case was reported to demonstrate the characteristic 18F-FDG PET CT findings for a semantic variant of PPA, which is a clinical syndrome eroding both speech and language.

Diagnostic des maladies neurodégénératives : intérêt de répéter dans le temps la TEP au 18 FDG. Analyse des pratiques du Centre Mémoire de Monaco

Une 2nde TEP au 18-FDG effectuee au moins 1 an apres the premiere est tres interessante pour preciser ou modifier le diagnostic, en particulier chez les patients avec un profil psychiatrique.



Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia

To identify predictors of Alzheimer's disease (AD) versus frontotemporal lobar degeneration pathology in primary progressive aphasia (PPA), and determine whether the AD pathology is atypically

Aphasia: Sudden and progressive

Primary progressive aphasia: Reversed asymmetry of atrophy and right hemisphere language dominance

The authors report that right hemisphere atrophy in a patient with PPA was associated with atypical right hemisphere dominance for language, which suggests that neuronal damage in PPA is tightly linked to the underlying anatomy of the language network.

Prominent hypometabolism of the right temporoparietal and frontal cortex in two left-handed patients with primary progressive aphasia

Two left-handed subjects with typical symptoms of the nonfluent form of PPA in whom 18F-FDG PET revealed an asymmetric right-hemispheric pattern of reduced glucose metabolism in the frontal and temporoparietal cortex support the hypothesis that PPA can be considered as a symptom complex rather than a disease entity.

Cognition and anatomy in three variants of primary progressive aphasia

Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes.

Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia

The relationships between language presentation, Aβ amyloidosis, and glucose metabolism in three PPA variants using [11C]‐Pittsburgh compound B and [18F]‐labeled fluorodeoxyglucose positron emission tomography are studied.

Primary progressive aphasia and kindred disorders.

Slowly progressive aphasia without generalized dementia

  • M. Mesulam
  • Psychology, Medicine
    Annals of neurology
  • 1982
Six right‐handed patients experienced a slowly progressing aphasic disorder without the additional intellectual and behavioral disturbances of dementia, and this condition may constitute a syndrome of relatively focal cerebral degeneration with a predilection for the left perisylvian region.

Frontotemporal lobar degeneration

Consensus criteria for the three prototypic syndromes-frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia-were developed by members of an international workshop on frontotem temporal lobar degeneration and ought to provide the foundation for research work into the neuropsychology, neuropathology, genetics, molecular biology, and epidemiology of these important clinical disorders.

Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?

These findings support a claim that the patients' deficits on both verbal and non-verbal tasks reflect progressive deterioration of an amodal integrative semantic memory system critically involving the rostral temporal lobes, rather than a combination of atrophy in the left language network and a separate bilateral ventrotemporal-fusiform network.