Primary Immunodeficiencies with Elevated IgE.

  title={Primary Immunodeficiencies with Elevated IgE.},
  author={Trine Hyrup Mogensen},
  journal={International reviews of immunology},
  volume={35 1},
In recent years a number of primary immunodeficiencies (PIDs) characterized by elevated Immunoglobulin E (IgE) levels have been uncovered and termed as Hyper-IgE syndrome (HIES). In addition to the elevated levels of IgE, patients with these PIDs display a spectrum of infections by staphylococci and fungi, and in some cases viruses, particularly affecting skin and lungs. Most of these PIDs also have a non-infectious phenotype, comprising musculoskeletal, vascular, and neurological abnormalities… CONTINUE READING


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