Primary Immunodeficiencies: A Field in Its Infancy

@article{Casanova2007PrimaryIA,
  title={Primary Immunodeficiencies: A Field in Its Infancy},
  author={Jean Laurent Casanova and Laurent Abel},
  journal={Science},
  year={2007},
  volume={317},
  pages={617 - 619}
}
A paradigm shift is occurring in the field of primary immunodeficiencies, with revision of the definition of these conditions and a considerable expansion of their limits. Inborn errors of immunity were initially thought to be confined to a few rare, familial, monogenic, recessive traits impairing the development or function of one or several leukocyte subsets and resulting in multiple, recurrent, opportunistic, and fatal infections in infancy. A growing number of exceptions to each of these… 

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...

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