Primary Immunodeficiencies: A Field in Its Infancy

@article{Casanova2007PrimaryIA,
  title={Primary Immunodeficiencies: A Field in Its Infancy},
  author={J. Casanova and L. Abel},
  journal={Science},
  year={2007},
  volume={317},
  pages={617 - 619}
}
  • J. Casanova, L. Abel
  • Published 2007
  • Medicine, Biology
  • Science
  • A paradigm shift is occurring in the field of primary immunodeficiencies, with revision of the definition of these conditions and a considerable expansion of their limits. Inborn errors of immunity were initially thought to be confined to a few rare, familial, monogenic, recessive traits impairing the development or function of one or several leukocyte subsets and resulting in multiple, recurrent, opportunistic, and fatal infections in infancy. A growing number of exceptions to each of these… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 42 REFERENCES
    ATM and related protein kinases: safeguarding genome integrity
    • 2,502
    • PDF
    Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency
    • 617