A case of primary and exclusive Hodgkin's disease of the thyroid gland in a 29-year-old woman and a review of the literature are described. Diagnosis with fine-needle aspiration biopsy (FNAB) was performed before surgery. The patient underwent subtotal thyroidectomy, followed by a radiotherapy dose of 46 Gy. Post-operative histological examination confirmed the cytological diagnosis without evidence of thyroiditis or lymphadenopathy. Five months after thyroidectomy, surgical staging confirmed the exclusive localization of the disease in the thyroid. The patient is followed up on an out-patient basis and is still in good health, 24 months after treatment.