Primary CNS lymphoma treated with combined intra-arterial ACNU and radiotherapy

@article{Sonoda2007PrimaryCL,
  title={Primary CNS lymphoma treated with combined intra-arterial ACNU and radiotherapy},
  author={Yukihiko Sonoda and Kouji Matsumoto and Yoshihisa Kakuto and Yoshinori Nishino and T Kumabe and Teiji Tominaga and Ryuichi Katakura},
  journal={Acta Neurochirurgica},
  year={2007},
  volume={149},
  pages={1183-1189}
}
Object. To assess whether nimustine (ACNU), a drug that can cross the blood brain barrier, combined with radiotherapy, improved the survival of patients with primary central nervous system lymphoma (PCNSL). Clinical materials and methods. Between 1995 and 2005, we treated 63 immunocompetent PCNSL patients with combination therapy consisting of intra-arterial ACNU (100 mg/m2) and whole brain radiotherapy (36–50 Gy). Their median age was 60 years (range 28–81). The median follow-up was 24 months… CONTINUE READING