Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis.

@article{MontecinoRodriguez1997PrimaryBC,
  title={Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis.},
  author={Encarnacion Montecino-Rodriguez and Ross G. Clark and Lyn Powell-Braxton and Kenneth Dorshkind},
  journal={Journal of immunology},
  year={1997},
  volume={159 6},
  pages={2712-9}
}
There has been considerable speculation that hormones produced in the anterior pituitary gland act as positive regulators of primary B cell development in the bone marrow. In order to identify endocrine factors that have such a role, B cell differentiation was examined in a panel of mice with genetic mutations that result in compromised production of one or more anterior pituitary hormones. This analysis demonstrated that the frequency of B lineage cells is significantly reduced in the dwarf… CONTINUE READING