Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth

  title={Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth},
  author={J D Iams and Roberto Romero and Jennifer Flatow Culhane and Robert L Goldenberg},
  journal={The Lancet},

WHO recommendation on the optimal mode of birth for women in refractory preterm labour

  • Medicine
  • 2019
This work states that it is critical to address the determinants of poor outcomes related to preterm birth to achieve further reductions in child mortality.

Preterm Birth in Low-resource Setting

  • Ali A Sungkar
  • Medicine
    Donald School Journal of Ultrasound in Obstetrics and Gynecology
  • 2021
Several risk factors have been identified and are avoidable and preventable, such as smoking, bacterial infection, poor nutritional status, and malnourished mothers.

Prevention of preterm birth.

Primary prevention of preterm birth

There is a need to revisit strategies to reduce the rate of preterm birth and numerous medical and surgical procedures have been used to treat or prevent spontaneous PTL.

Therapeutic modalities with antenatal corticosteroids in preterm delivery

It is concluded that the regimen of unique dose offers greater therapeutic advantages and less adverse effects.

Reducing Recurrent Preterm Births: Best Evidence for Transitioning to Predictive and Preventative Strategies

There is adequate evidence in the literature to justify clinical management guidelines that may impact the PTB rate: smoking cessation, treatment of asymptomatic bacteriuria, transvaginal ultrasonography of the cervix, administration of vaginal progesterone or 17&agr;-hydroxyprogesterone caproate, cerclage, and fetal fibronectin.

Prevention of preterm birth based on short cervix: progesterone.

This review summarizes the evidence (level A evidence) of the effectiveness of progesterone on the rate of preterm birth.

Incidence and outcome of preterm deliveries in Mother and Child Hospital Akure, Southwestern Nigeria

To determine the incidence of preterm delivery in the Mother and Child Hospital, Akure, to investigate the outcome and explore the relationship between birth weight and neonatal survival, a large number of babies were preterm.



Preterm Birth: Causes, Consequences, and Prevention

The increasing prevalence of preterm birth in the United States is a complex public health problem that requires multifaceted solutions and this book addresses the need for research involving clinical, basic, behavioral, and social science disciplines.

Evaluation of a Preterm Birth Prevention Program: Preliminary Report

It is suggested that the preterm birth prevention program may have been instrumental in reducing the pre term delivery rate by enabling early and effective long-term tocolytic therapy.

Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.

It is recommended that women with expectantly managed PPROM remote from term receive antibiotics to reduce infant morbidity and among GBS-negative women, significant pregnancy prolongation was seen with antibiotics.

Treatment of Vaginal Infections to Prevent Preterm Birth: A Meta-Analysis

When membranes and amniotic fluid were cultured from women undergoing cesarean delivery with and without labor at various gestational ages, there was an inverse association between positive cultures and gestational age, suggesting that microbial colonization is more frequent among spontaneous preterm births at lowergestational ages.

Prenatal administration of progesterone for preventing preterm birth.

Intramuscular progesterone is associated with a reduction in the risk of preterm birth less than 37 weeks' gestation, and infant birthweight less than 2500 grams.

The effect of birth hospital type on the outcome of very low birth weight infants.

The current study lends strong support to existing Academy of Pediatrics and American College of Obstetricians and Gynecologists recommendations that deliveries at <32 weeks' gestational age occur at subspecialty perinatal centers.

Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor.

Transdermal nitroglycerin may reduce neonatal morbidity and mortality as a result of decreased risk of birth before 28 weeks as well as other maternal side effects.

Recurrent preterm birth.

The body of literature describing the risk of recurrence of spontaneous and indicated preterm birth is reviewed and the factors which modify the risk are discussed (a short sonographic cervical length and a positive cervicovaginal fetal fibronectin test).