Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity.


A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver stage infection. 
DOI: 10.1016/j.ejmech.2015.06.045


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