Primaquine-induced hemolytic anemia: formation of free radicals in rat erythrocytes exposed to 6-methoxy-8-hydroxylaminoquinoline.

@article{Bolchoz2002PrimaquineinducedHA,
  title={Primaquine-induced hemolytic anemia: formation of free radicals in rat erythrocytes exposed to 6-methoxy-8-hydroxylaminoquinoline.},
  author={Laura J C Bolchoz and Andrew Keith Gelasco and David J. Jollow and D C Mcmillan},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={303 3},
  pages={
          1121-9
        }
}
Primaquine is an important antimalarial drug that is often dose-limited in therapy by the onset of hemolytic anemia. We have shown recently that an N-hydroxy metabolite of primaquine, 6-methoxy-8-hydroxylaminoquinoline (MAQ-NOH), is a direct-acting hemolytic agent in rat red cells and that the hemolytic activity of this metabolite is associated with GSH oxidation and oxidative damage to both membrane lipids and skeletal proteins. To determine whether the formation of free radicals may be… CONTINUE READING

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