Prima-1 induces apoptosis in bladder cancer cell lines by activating p53

  title={Prima-1 induces apoptosis in bladder cancer cell lines by activating p53},
  author={Camila Berfort Piantino and Sabrina T Reis and Nayara I Viana and Iran Amorim Silva and Denis Reis Morais and Alberto Azoubel Antunes and Nelson G Dip and Miguel Srougi and Katia R M Leite},
OBJECTIVES Bladder cancer represents 3% of all carcinomas in the Brazilian population and ranks second in incidence among urological tumors, after prostate cancer. The loss of p53 function is the main genetic alteration related to the development of high-grade muscle-invasive disease. Prima-1 is a small molecule that restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. Our aim was to investigate the ability of Prima-1 to induce apoptosis after… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations

Stimulation of suicidal erythrocyte death by PRIMA-1.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2015


Publications referenced by this paper.
Showing 1-10 of 37 references

Deconstructing p53 transcriptional networks in tumor suppression.

Trends in cell biology • 2012
View 10 Excerpts
Highly Influenced

Bladder Cancer

Debra T. Silverman SSD, Lee E. Moore, Nathaniel Rothman
View 3 Excerpts
Highly Influenced

Reactivation of p53 mutants by p53 reactivation and induction of massive apoptosis in thyroid cancer cells

RL Messina, M Sanfilippo, +3 authors ML Nicolosi
Int J Cancer • 2012
View 1 Excerpt

Global cancer statistics.

CA: a cancer journal for clinicians • 2011

Similar Papers

Loading similar papers…