Prima-1 induces apoptosis in bladder cancer cell lines by activating p53

@inproceedings{Piantino2013Prima1IA,
  title={Prima-1 induces apoptosis in bladder cancer cell lines by activating p53},
  author={Camila Berfort Piantino and Sabrina T Reis and Nayara I Viana and Iran Amorim Silva and Denis Reis Morais and Alberto Azoubel Antunes and Nelson G Dip and Miguel Srougi and Katia R M Leite},
  booktitle={Clinics},
  year={2013}
}
OBJECTIVES Bladder cancer represents 3% of all carcinomas in the Brazilian population and ranks second in incidence among urological tumors, after prostate cancer. The loss of p53 function is the main genetic alteration related to the development of high-grade muscle-invasive disease. Prima-1 is a small molecule that restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. Our aim was to investigate the ability of Prima-1 to induce apoptosis after… CONTINUE READING

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