PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells


G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epigenetic instability. Here we report that PrimPol, a recently described primase-polymerase (PrimPol), plays a crucial role in the bypass of leading… (More)
DOI: 10.1016/j.molcel.2015.10.038