Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.

@article{Glimm2001PreviouslyUH,
  title={Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.},
  author={Hanno Glimm and Wolfgang Eisterer and Kangryul Lee and Johanne Cashman and Tessa L Holyoake and Frank Nicolini and Leonard D Shultz and Christof von Kalle and Connie J. Eaves},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 2},
  pages={
          199-206
        }
}
Increasing use of purified or cultured human hematopoietic cells as transplants has revealed an urgent need for better methods to predict the speed and durability of their engraftment potential. We now show that NOD/SCID-beta2 microglobulin-null (NOD/SCID-beta2m-/-) mice are sequentially engrafted by two distinct and previously unrecognized populations of transplantable human short-term repopulating hematopoietic cells (STRCs), neither of which efficiently engraft NOD/SCID mice. One is… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 37 references

β2 microglobulin-deficient (B2mnull) NOD/SCID mice are excellent recipients for studying human stem cell function

  • O Kollet
  • 2000
1 Excerpt

Anatomy and physiology of hematopoiesis

  • C. J. Eaves, A. C. Eaves
  • In Childhood leukemias. C.-H. Pui,
  • 1999
1 Excerpt