Previous history of chronic stress changes the transcriptional response to glucocorticoid challenge in the dentate gyrus region of the male rat hippocampus.

@article{Datson2013PreviousHO,
  title={Previous history of chronic stress changes the transcriptional response to glucocorticoid challenge in the dentate gyrus region of the male rat hippocampus.},
  author={Nicole A Datson and Jessica M. E. van den Oever and Oksana B Korobko and Ana Mar{\'i}a Magari{\~n}os and Edo Ronald de Kloet and Bruce S. McEwen},
  journal={Endocrinology},
  year={2013},
  volume={154 9},
  pages={3261-72}
}
Chronic stress is a risk factor for several neuropsychiatric diseases, such as depression and psychosis. In response to stress glucocorticoids (GCs) are secreted that bind to mineralocorticoid and glucocorticoid receptors, ligand-activated transcription factors that regulate the transcription of gene networks in the brain necessary for coping with stress, recovery, and adaptation. Chronic stress particularly affects the dentate gyrus (DG) subregion of the hippocampus, causing several functional… CONTINUE READING
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