Previous experience of withdrawal from chronic diazepam ameliorates the aversiveness of precipitated withdrawal and reduces withdrawal‐induced c‐fos expression in nucleus accumbens

@article{Dunworth2000PreviousEO,
  title={Previous experience of withdrawal from chronic diazepam ameliorates the aversiveness of precipitated withdrawal and reduces withdrawal‐induced c‐fos expression in nucleus accumbens},
  author={S. J. Dunworth and A. Mead and D. Stephens},
  journal={European Journal of Neuroscience},
  year={2000},
  volume={12}
}
Flumazenil (20 mg/kg, i.p.)‐precipitated withdrawal from chronic treatment with diazepam (DZP, 15 mg/kg, s.c. in sesame oil for 21 days) resulted in a decreased seizure threshold to the convulsant, pentylenetetrazole (PTZ), infused into the tail vein; withdrawal from 21‐day chronic diazepam treatment, interspersed with two periods of drug withdrawal, resulted in a greater decrease in convulsant threshold. A separate experiment showed that consumption of a sucrose solution immediately prior to… Expand
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