Previous Exposure to THC Alters the Reinforcing Efficacy and Anxiety-Related Effects of Cocaine in Rats

@article{Panlilio2007PreviousET,
  title={Previous Exposure to THC Alters the Reinforcing Efficacy and Anxiety-Related Effects of Cocaine in Rats},
  author={Leigh V. Panlilio and Marcello Solinas and Stephanie A. Matthews and Steven R. Goldberg},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={646-657}
}
The hypothesis that prior cannabis exposure increases the likelihood of becoming addicted to other drugs can be evaluated by giving rats a history of tetrahydrocannabinol (THC) exposure, then allowing them to self-administer other drugs. In Experiment 1, THC pre-exposure did not alter the acquisition of cocaine self-administration or the amount of cocaine taken under a fixed-ratio 1 (FR1) schedule, with one response required for each injection. Under a progressive-ratio schedule, with the… CONTINUE READING

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