Preventive treatment of migraine.

  title={Preventive treatment of migraine.},
  author={Stephen David Silberstein},
  journal={Trends in pharmacological sciences},
  volume={27 8},
Migraine is a common episodic pain disorder, the treatment of which can be acute to stop an attack or preventive to reduce the frequency, duration or severity of attacks. Preventive treatment is used when attacks are frequent or disabling. Many different medication groups are used for preventive treatment, including beta-blockers, antidepressants and antiepileptic drugs. Their mechanisms of action include raising the threshold to migraine activation, enhancing antinociception, inhibiting… CONTINUE READING
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