Preventive surgery for colon cancer in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer syndrome

@article{Moslein2003PreventiveSF,
  title={Preventive surgery for colon cancer in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer syndrome},
  author={G. Möslein and S. Pistorius and H. Saeger and H. Schackert},
  journal={Langenbeck's Archives of Surgery},
  year={2003},
  volume={388},
  pages={9-16}
}
BackgroundA better understanding of the molecular basis of hereditary colorectal cancer syndromes such as hereditary nonpolyposis colorectal cancer syndrome (HNPCC) and familial adenomatous polyposis (FAP) has profound consequences for both the diagnosis and (prophylactic) treatment of (pre)malignant neoplastic lesions.DiscussionSequence analysis of the underlying genes for these conditions and the detection of disease-causing genetic alterations in an index patient enable predictive testing… Expand
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Familial Adenomatous Polyposis
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