Preventive surgery for colon cancer in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer syndrome

@article{Mslein2003PreventiveSF,
  title={Preventive surgery for colon cancer in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer syndrome},
  author={Gabriela M{\"o}slein and Steffen R. Pistorius and Hans-Detlev Saeger and Hans Konrad Schackert},
  journal={Langenbeck's Archives of Surgery},
  year={2003},
  volume={388},
  pages={9-16}
}
BackgroundA better understanding of the molecular basis of hereditary colorectal cancer syndromes such as hereditary nonpolyposis colorectal cancer syndrome (HNPCC) and familial adenomatous polyposis (FAP) has profound consequences for both the diagnosis and (prophylactic) treatment of (pre)malignant neoplastic lesions.DiscussionSequence analysis of the underlying genes for these conditions and the detection of disease-causing genetic alterations in an index patient enable predictive testing… 
Critical issues in the identification and management of patients with hereditary non-polyposis colorectal cancer
Awareness for familial occurrence of colorectal cancer has increased but still many cases remain undetected.Diagnosis of HNPCC syndrome is of great importance since it allows early detection and
Lynch syndrome: implications for the surgeon.
TLDR
The diagnosis and management of Lynch syndrome will be reviewed, with emphasis on the implications for the surgeon.
Surgical Options for Familial Adenomatous Polyposis
TLDR
It is now clear that the different patterns of FAP are based on different APC mutations, and it is important to offer a tailored approach, where the type of operation and the timing is based on aggressiveness of the disease and the risk of other manifestations such as desmoid tumors.
Familial Adenomatous Polyposis
TLDR
Genetic testing has evolved over the past decade to play a key role in identifying at-risk individuals and assisting in recommendations made to these patients and their families with regard to screening, surgical treatment, and surveillance.
Hereditary Nonpolyposis Colorectal Cancer
TLDR
The current understanding of the genetics of HNPCC, the various phenotypic expressions, genetic testing, surveillance, and current recommendations of management of this familial cancer syndrome are discussed.
Surveillance in Lynch Syndrome
TLDR
Screening for colorectal adenomas and carcinomas by regular colonoscopies is the main topic of the present review and the value of screening for other extracolonic cancers remains also uncertain.
Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.
TLDR
Adenoma would appear to be the most important lesion preceding cancer formation in Lynch syndrome and removal of adenomas decreases the risk for colorectal cancer (CRC).
Polyp Progression in Paediatric Patients with Familial Adenomatous Polyposis - A Single Centre Experience.
TLDR
The results suggest that adenoma number remains relatively stable in the majority of children under surveillance, and Tailored surveillance intervals according to phenotype are a more appropriate strategy as recommended by recently published guidelines.
Wireless capsule endoscopy in adolescents with familial adenomatous polyposis
TLDR
Wireless capsule endoscopy is feasible and well-tolerated as a first screening examination in adolescent patients, but it cannot be used as alternative to the colonoscopy, but could improve compliance with colonoscope, and increase early adherence to a surveillance program.
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