The human health impact of AFB1 exposure is widespread in developing countries, is known to cause teratogenicity, immunotoxicity, hepatotoxicity and even death in farm animals and humans. As information has accumulated on toxicological effects of AFB1, preventive strategies whose objective is to reduce the risks to human health have been implemented. Chemical, physical and biological strategies for the control and prevention of aflatoxicosis and AFB1-associated diseases are described. In a primary prevention trial, the purpose is to reduce exposure to AFB1 in the diet. In secondary prevention trials, one goal is to modulate the metabolism of ingested AFB1 to enhance detoxification processes, thereby reducing internal doses and subsequent risk. This information suggested the probable application of different strategies as an alternative method to avoid the effects produced by the AFB1. The extent to which these interventions may ultimately modify the hazard in high-risk populations is an area that needs further investigation.