Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.

@article{Xu2009PreventiveEO,
  title={Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.},
  author={Gang Xu and Takuya Watanabe and Yoshitaka Iso and Shinji Koba and Tetsuo Sakai and Masaharu Nagashima and Shigeko Arita and Shigeki Hongo and Hidekazu Ota and Youichi Kobayashi and Akira Miyazaki and Tsutomu Hirano},
  journal={Circulation research},
  year={2009},
  volume={105 5},
  pages={500-10}
}
RATIONALE Human heregulins, neuregulin-1 type I polypeptides that activate proliferation, differentiation, and survival of glial cells, neurons, and myocytes, are expressed in macrophage foam cells within human coronary atherosclerotic lesions. Macrophage foam cell formation, characterized by cholesterol ester accumulation, is modulated by scavenger receptor class A (SR-A), acyl-coenzyme A:cholesterol acyltransferase (ACAT)1, and ATP-binding cassette transporter (ABC)A1. OBJECTIVE The present… CONTINUE READING

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