Preventive effects of citrulline on Western diet-induced non-alcoholic fatty liver disease in rats.

@article{Jegatheesan2016PreventiveEO,
  title={Preventive effects of citrulline on Western diet-induced non-alcoholic fatty liver disease in rats.},
  author={Prasanthi Jegatheesan and St{\'e}phanie Beutheu and Kim Freese and Anne-Judith Waligora-Dupriet and Esther Nubret and M J Butel and Ina Bergheim and Jean-Pascal De Bandt},
  journal={The British journal of nutrition},
  year={2016},
  volume={116 2},
  pages={191-203}
}
A Western diet induces insulin resistance, liver steatosis (non-alcoholic fatty liver disease (NAFLD)) and intestinal dysbiosis, leading to increased gut permeability and bacterial translocation, thus contributing to the progression of NAFLD to non-alcoholic steatohepatitis. In the present study, we sought, in a model of Western diet-induced NAFLD, to determine whether citrulline (Cit), an amino acid that regulates protein and energy metabolism, could decrease Western diet-induced liver… CONTINUE READING
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