Preventive effects of cilostazol against the development of shunt-dependent hydrocephalus after subarachnoid hemorrhage.

@article{Nakatsuka2017PreventiveEO,
  title={Preventive effects of cilostazol against the development of shunt-dependent hydrocephalus after subarachnoid hemorrhage.},
  author={Yoshinari Nakatsuka and Fumihiro Kawakita and Ryuta Yasuda and Yasuyuki Umeda and Naoki Toma and Hiroshi Sakaida and Hidenori Suzuki},
  journal={Journal of neurosurgery},
  year={2017},
  volume={127 2},
  pages={
          319-326
        }
}
OBJECTIVE Chronic hydrocephalus develops in association with the induction of tenascin-C (TNC), a matricellular protein, after aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to examine if cilostazol, a selective inhibitor of phosphodiesterase Type III, suppresses the development of chronic hydrocephalus by inhibiting TNC induction in aneurysmal SAH patients. METHODS The authors retrospectively reviewed the factors influencing the development of chronic shunt-dependent… CONTINUE READING
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