Preventive effects of β-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts.

@article{Cherng2012PreventiveEO,
  title={Preventive effects of $\beta$-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts.},
  author={Jong-yuh Cherng and Li Yin Chen and Mei Fen Shih},
  journal={The American journal of Chinese medicine},
  year={2012},
  volume={40 2},
  pages={
          387-98
        }
}
Solar UV radiation damages human skin by affecting skin tone and resiliency and leads to premature aging (photoaging). The skin damage is caused by the activation of the AP-1 transcription factor, which increases matrix metalloproteinase (MMP) expression and collagen degradation. An increase of interleukin (IL)-6 is also correlated with the activation of MMP-1 expression. β-thujaplicin has shown both acaricidal and antimicrobial activities. Also, β-thujaplicin has been shown to be protective… 
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