Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPA.

@article{Kang2001PreventiveEO,
  title={Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPA.},
  author={Kyung Sun Kang and Jun Won Yun and B Yoon and Yeun Keun Lim and Yong Sup Lee},
  journal={Cancer letters},
  year={2001},
  volume={166 2},
  pages={147-53}
}
Gap junctional intercellular communication (GJIC) is thought to be essential for maintaining cellular homeostasis and growth control. In order to detect any protective agent against tumor formation, we examined the anticarcinogenic effect of a germanium dioxide (GeO(2)) using a model system of GJIC in F344 rat liver epithelial cells, named WB cells. 12-O-tetradecanoylphorbol-13-acetate (TPA), known as tumor promoters, inhibited GJIC in the epithelial cells as determined by the scrape loading… CONTINUE READING