Preventive effect of diethyldithiocarbamate on experimental diabetes produced by dithisone and 8-oxychinoline.
@article{Lazaris1979PreventiveEO,
title={Preventive effect of diethyldithiocarbamate on experimental diabetes produced by dithisone and 8-oxychinoline.},
author={J. Lazaris and F. J. Babelskyi},
journal={Endocrinologia experimentalis},
year={1979},
volume={13 1},
pages={
39-51
}
}Diethyldithiocarbamate sodium (DDC)--a compound forming complexes with metal ions-did not change the structure of endocrine pancreas and did not affect the glycemia after the repeated administration of a dose of 250 mg kg-1 while a single dose of 500 or 1000 mg kg-1 increased the glycemia for 2 to 4 h in most of rabbits tested. DDC injected in similar doses prevented a diabetogenic action of dithisone and of a number of 8-oxichinoline derivatives. This effect appeared very rapidly and persisted… Expand
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