Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease

@article{Park2004PreventiveEO,
  title={Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease},
  author={Soon-Won Park and Shinhong Kim and Kyu-Hyun Park and Sang-doo Kim and Chi-Dug Kang},
  journal={Neuroscience Letters},
  year={2004},
  volume={363},
  pages={243-246}
}
Oxidative stress to dopaminergic neurons is believed to be one of the causes of neurodegeneration in Parkinson's disease (PD). It was investigated whether N-acetylcysteine (NAC) and l-2-oxothiazolidine-4-carboxylate (OTC) have a preventive effect in an oxidative stress-induced model of PD. We found that NAC and OTC prevent degradation of PARP during auto-oxidized dopamine- or auto-oxidized L-DOPA-induced apoptosis in PC12 cells. In an animal model study, NAC and OTC showed a preventive effect… CONTINUE READING

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