Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats.

@article{Yamamoto2011PreventiveEO,
  title={Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats.},
  author={Shinya Yamamoto and Bunta Watanabe and Jun Hiratake and Ryosuke Tanaka and Mamoru Ohkita and Yasuo Matsumura},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={339 3},
  pages={945-51}
}
GGsTop [2-amino-4-{[3-(carboxymethyl)phenyl](methyl)phosphono}butanoic acid], is a novel, highly selective, and irreversible γ-glutamyl transpeptidase (GGT) inhibitor with no inhibitory activity on glutamine amidotransferases. In this study, we investigated the effects of treatment with GGsTop on ischemia/reperfusion-induced renal injury in uninephrectomized rats. Ischemic acute kidney injury (AKI) was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion 2… CONTINUE READING

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