Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice.

@article{Zhou2008PreventiveBN,
  title={Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice.},
  author={Zhe Zhou and Diana Treis and Susanne C Schubert and Maria Harm and Jolanthe Schatterny and Stephanie Hirtz and Julia Duerr and Richard C. Boucher and Marcus A Mall},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={178 12},
  pages={1245-56}
}
RATIONALE Increased airway Na(+) absorption mediated by epithelial Na(+) channels (ENaC) is a characteristic abnormality in the pathogenesis of cystic fibrosis (CF) lung disease. However, inhalation therapy with the ENaC blocker amiloride did not have therapeutic benefits in patients with CF with established lung disease. OBJECTIVES We hypothesized that preventive inhibition of increased Na(+) absorption in a structurally normal lung may be required for effective therapy of CF lung disease in… CONTINUE READING

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