Preventive aspirin treatment of streptozotocin induced diabetes: blockage of oxidative status and revertion of heme enzymes inhibition.

@article{Caballero2000PreventiveAT,
  title={Preventive aspirin treatment of streptozotocin induced diabetes: blockage of oxidative status and revertion of heme enzymes inhibition.},
  author={Fabiana A Caballero and Esther Noem{\'i} Gerez and Alcira Batlle and Elba Susana Vazquez},
  journal={Chemico-biological interactions},
  year={2000},
  volume={126 3},
  pages={215-25}
}
Some late complications of diabetes are associated with alterations in the structure and function of proteins due to glycation and free radicals generation. Aspirin inhibits protein glycation by acetylation of free amino groups. In the diabetic status, it was demonstrated that several enzymes of heme pathway were diminished. The aim of this work has been to investigate the in vivo effect of short and long term treatment with acetylsalicylic acid in streptozotocin induced diabetic mice. In both… CONTINUE READING
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