Preventive and therapeutic effects of Lactobacillus paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice.

@article{Simeoli2015PreventiveAT,
  title={Preventive and therapeutic effects of Lactobacillus paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice.},
  author={Raffaele Simeoli and Giuseppina Mattace Raso and Adriano Lama and Claudio Pirozzi and Anna Santoro and Francesca Di Guida and Marco Sanges and Ezra Aksoy and Antonio Calignano and Agesilao D'arienzo and Rosaria Meli},
  journal={The Journal of nutrition},
  year={2015},
  volume={145 6},
  pages={
          1202-10
        }
}
BACKGROUND Although gut microbiota perturbation is recognized as a main contributing factor to the pathogenesis of inflammatory bowel disease, synbiotic therapies, as prevention or treatment, have remained overlooked. OBJECTIVE To verify whether Lactobacillus paracasei B21060-based synbiotic therapy could prevent or repair colon damage in a mouse model of colitis, we performed treatments before and after colitis induction. METHODS The experimental study lasted 19 d. Experimental colitis was… Expand
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