Preventive and therapeutic anti-TNF-α therapy with pentoxifylline decreases arthritis and the associated periodontal co-morbidity in mice.

@article{QueirozJnior2013PreventiveAT,
  title={Preventive and therapeutic anti-TNF-α therapy with pentoxifylline decreases arthritis and the associated periodontal co-morbidity in mice.},
  author={Celso Martins Queiroz-J{\'u}nior and Rafaela Leal Costa Bessoni and Vivian Vasconcelos Costa and Danielle G Souza and Mauro Martins Teixeira and Tarc{\'i}lia Aparecida da Silva},
  journal={Life sciences},
  year={2013},
  volume={93 9-11},
  pages={
          423-8
        }
}
AIMS The association between rheumatoid arthritis (RA) and periodontal disease (PD) has long been studied and some reports suggest that treating RA may improve the associated PD, and vice versa. This study aimed to evaluate the effects of an anti-tumor necrosis factor (TNF)-α therapy with pentoxifylline (PTX) in an experimental model of RA-associated PD. MAIN METHODS Male C57BL/6 mice were subjected to chronic antigen-induced arthritis (AIA) and daily treated with PTX (50mg/kg, i.p.) using… CONTINUE READING
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