Prevention of vertical transmission of HIV-1 in resource-limited settings

@article{Coutsoudis2010PreventionOV,
  title={Prevention of vertical transmission of HIV-1 in resource-limited settings},
  author={Anna Coutsoudis and Leith Kwaan and Mairi Thomson},
  journal={Expert Review of Anti-infective Therapy},
  year={2010},
  volume={8},
  pages={1163 - 1175}
}
One of the most exciting areas of HIV research is that of prevention of vertical transmission from mother to child, since it accounts for 90% of childhood HIV infections, and therefore prevention in this context has an enormous potential impact on the spread of HIV among children. Focused research has yielded highly successful strategies for reducing infant infection rates, particularly in the developed world, and much work is underway to implement appropriate strategies in resource-limited… 
Translation of Biomedical Prevention Strategies for HIV: Prospects and Pitfalls
TLDR
A review identifies the major biomedical approaches demonstrated to be efficacious that are now available and highlights the need for behavioral risk reduction and adherence as essential components of any biomedical approach.
Community-based approaches for prevention of mother to child transmission in resource-poor settings: a social ecological review
TLDR
This paper reviews community‐based approaches that have been used in resource‐limited settings to increase rates of PMTCT enrolment, retention in care and successful treatment outcomes and aims to identify which interventions work, why they may do so and what knowledge gaps remain.
A Retrospective Study of Impact of PPTCT on HIV Trends, Maternal and Perinatal Outcome
TLDR
The main aim of the study is to appreciate the declining trend of HIV in babies with HIV positive mother by implementation of PPTCT services.
Current knowledge and future research on infant feeding in the context of HIV: basic, clinical, behavioral, and programmatic perspectives.
TLDR
The benefits and risks of breastmilk, the evolution of recommended infant feeding modalities in high-income and low-income countries in the last two decades, and contextualize the recently revised guidelines for infant feeding in the context of HIV current knowledge are described.
Surveillance of HIV drug resistance in children receiving antiretroviral therapy: a pilot study of the World Health Organization's generic protocol in Maputo, Mozambique.
Between 2007 and 2008, the Mozambique Ministry of Health conducted an assessment of human immunodeficiency virus drug resistance (HIVDR) using World Health Organization (WHO) methods in a cohort of
Study on HIV prevalence in pregnant women and association of risk factors favoring its transmission
TLDR
The prevalence of HIV among pregnant women and assessment of various risk factors which favors HIV transmission are known and pregnant women with HIV should diagnose as soon as possible to reduce mother to child transmission.
Parental Influence on HIV Vertical Transmission in Kenya
TLDR
Assessment of the association between parental HIV knowledge, attitudes and risk reduction practices, and HIV vertical transmission in Kenya indicated gaps in knowledge and information packaging, which might be utilized to develop and implement HIV prevention strategies.
Implementation of Context Specific Diagnostics, Strategies and Resources for PMTCT Scale-up Programming in Conflict Affected Communities in Jos, Nigeria
The 2013 WHO HIV guidelines provided effective antiretroviral regimens to reduce perinatal transmission to below 2%. The option-B approach of providing antiretroviral drugs was adopted by Nigeria,
HIV/AIDS in Children: Current Update
TLDR
Every pregnant woman should be tested for HIV to have a better chance of preventing transmission to her unborn child and there is no vaccine to prevent HIV and AIDS although researchers are working to develop one.
...
...

References

SHOWING 1-10 OF 130 REFERENCES
Prevention of mother to child transmission of HIV
TLDR
The factors affecting the transmission of HIV, strategies for prevention of MTCT with special reference to use of nevirapine and breastfeeding practices in HIV positive mother are focused on.
Implementing Programs for the Prevention of Mother-to-Child HIV Transmission in Resource-Constrained Settings: Horizons Studies, 1999–2007
TLDR
An assessment of the findings of Horizons studies on PMTCT interventions from 1999 to 2007 is provided and needs for follow-on efforts are identified.
Prevention of mother-to-child transmission of HIV in Zambia: implementing efficacious ARV regimens in primary health centers
TLDR
Efficacious ARV regimens beyond sdNVP can be implemented in resource-constrained PHCs, and initiation of cART among HIV-positive pregnant women was associated with the PHC's capacity to provide care and antiretroviral treatment services.
Prevention of Mother-to-Child Transmission of HIV-1 Using Highly Active Antiretroviral Therapy in Rural Yunnan, China
TLDR
This project provides a model for China to scale up its efforts to prevent mother-to-child transmission of HIV-1 and demonstrates that HAART for all infected pregnant women is effective with a vertical transmission rate of ∼1%.
Antiretroviral Treatment and Prevention of Peripartum and Postnatal HIV Transmission in West Africa: Evaluation of a Two-Tiered Approach
TLDR
This two-tiered strategy appears to be safe and highly effective for short- and long-term PMTCT in resource-constrained settings and indicates a further benefit of access to HAART for pregnant women who need treatment for their own health.
Increasing the uptake of prevention of mother-to-child transmission of HIV services in a resource-limited setting
TLDR
Uptake of PMTCT services in resource-limited settings can be improved by utilizing innovative alternatives to mitigate the effects of human resource shortage such as by providing technical assistance and mentorship beyond regular training courses.
Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000–2006
TLDR
Current options for treatment and delivery offered to pregnant women according to British guidelines appear to be effective, and sustained low HIV transmission rates following different combinations of interventions in this large unselected population are encouraging.
Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1.
TLDR
Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.
Breastfeeding and AIDS in the developing world
TLDR
Promoting exclusive breastfeeding and assuring antiretroviral treatment for women with advanced HIV disease will likely prevent the majority of needless maternal and infant deaths.
Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission.
TLDR
Extended prophylaxis with ne virapine or with nevirapine and zidovudine for the first 14 weeks of life significantly reduced postnatal HIV-1 infection in 9-month-old infants.
...
...