Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI.

@article{Tucker2009PreventionOV,
  title={Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI.},
  author={Erik Ian Tucker and Ulla M. Marzec and Tara C. White and Sawan Hurst and Sandra Rugonyi and Owen J T McCarty and David Gailani and Andr{\'a}s Gruber and Stephen R. Hanson},
  journal={Blood},
  year={2009},
  volume={113 4},
  pages={
          936-44
        }
}
The protease thrombin is required for normal hemostasis and pathologic thrombogenesis. Since the mechanism of coagulation factor XI (FXI)-dependent thrombus growth remains unclear, we investigated the contribution of FXI to thrombus formation in a primate thrombosis model. Pretreatment of baboons with a novel anti-human FXI monoclonal antibody (aXIMab; 2 mg/kg) inhibited plasma FXI by at least 99% for 10 days, and suppressed thrombin-antithrombin (TAT) complex and beta-thromboglobulin (betaTG… CONTINUE READING

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