Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat.

@article{McCaleb1988PreventionOU,
  title={Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat.},
  author={M. L. McCaleb and Janet Sredy and Jenni E Millen and Debra Ackerman and D M Dvornik},
  journal={The Journal of diabetic complications},
  year={1988},
  volume={2 1},
  pages={16-8}
}
Recent clinical data strongly suggest that elevated urinary albumin excretion (UAE) identifies diabetic subjects at risk of developing nephropathy. Elevated UAE is attributed to increased transglomerular pressure, which is associated with poor metabolic control in rats. Because excess glucose in diabetes is metabolized via the polyol pathway, we were interested in whether the diabetes-induced elevation in UAE in rats could be prevented by inhibiting aldose reductase (AR), the first enzyme in… CONTINUE READING