Corpus ID: 10959940

Prevention of type 1 diabetes: from the view point of beta cell damage.

@article{Kawasaki2004PreventionOT,
  title={Prevention of type 1 diabetes: from the view point of beta cell damage.},
  author={E. Kawasaki and N. Abiru and K. Eguchi},
  journal={Diabetes research and clinical practice},
  year={2004},
  volume={66 Suppl 1},
  pages={
          S27-32
        }
}
The hallmark of immune-mediated type 1 diabetes is T cell-mediated destruction of the insulin-producing beta cells in the islets, which results from an imbalance between disease promoting factors and protective elements. The precise mechanisms of beta cell destruction leading to diabetes remain unclear. There are many molecules, including Fas ligand (FasL) and cytokines, such as IL-1, TNF-alpha and IFN-gamma that cause release of other cytokine-mediators that have potential to damage the beta… Expand
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