Prevention of tissue damage: Inhibition of Myeloperoxidase mediated inactivation of α1 inhibitor by N-acetyl cysteine, Glutathione, and Methionine


The ability of the sulphur compounds, N-acetyl cysteine, Methionine, and Glutathione to prevent inactivation of α1 inhibitor by Myeloperoxidase-H2O2-Cl−-system was investigated in vitro with purified components. The Myeloperoxidase system, or its main product HOCl by itself, readily abrogated the ability of α1 inhibitor to inhibit elastase. This… (More)
DOI: 10.1007/BF02009054


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