Prevention of the wortmannin-induced inhibition of phosphoinositide 3-kinase by sulfhydryl reducing agents.

@article{Isosaki2011PreventionOT,
  title={Prevention of the wortmannin-induced inhibition of phosphoinositide 3-kinase by sulfhydryl reducing agents.},
  author={Minoru Isosaki and Hitoshi Nakayama and Yoji Kyotani and Jing Zhao and Sayuko Tomita and Hiroyasu Satoh and Masanori Yoshizumi},
  journal={Pharmacological reports : PR},
  year={2011},
  volume={63 3},
  pages={733-9}
}
The effects of the sulfhydryl reducing agents 2-mercaptoethanol and dithiothreitol on wortmannin-induced inhibition of phosphoinositide 3-kinase (PI3K) were studied in order to examine whether the sulfhydryl reducing agents directly affect the wortmannin inhibition of PI3K. These reducing agents are commonly used to stabilize enzyme structures by… CONTINUE READING