Prevention of the surface resorption of bone grafts by topical application of bisphosphonate on different carrier materials

@article{Mller2014PreventionOT,
  title={Prevention of the surface resorption of bone grafts by topical application of bisphosphonate on different carrier materials},
  author={Bj{\"o}rn M{\"o}ller and J. Wiltfang and Yahya Açil and Matthias Gierloff and Sebastian Lippross and H. Terheyden},
  journal={Clinical Oral Investigations},
  year={2014},
  volume={18},
  pages={2203-2211}
}
The hypothesis of the present study was that topically applied bisphosphonate (BP) on a collagen membrane or alternatively bovine bone mineral prevents surface resorption of onlay bone grafts. In eight adult pigs, bone blocks were harvested bilaterally from the mandible and fixed to the lateral cortex of the horizontal ramus to simulate a ridge augmentation. In a split-mouth study design, we used alendronate in aqueous solution (1 mg/ml) on the test-side in three different ways: on a collagen… CONTINUE READING