Prevention of the development of heart failure and the regression of cardiac hypertrophy by captopril in the spontaneously hypertensive rat.

@article{Pfeffer1983PreventionOT,
  title={Prevention of the development of heart failure and the regression of cardiac hypertrophy by captopril in the spontaneously hypertensive rat.},
  author={Janice M. Pfeffer and Marc Pfeffer and Israel Mirsky and Eugene Braunwald},
  journal={European heart journal},
  year={1983},
  volume={4 Suppl A},
  pages={143-8}
}
The spontaneously hypertensive rat (SHR) exhibits both a compensated phase of cardiac hypertrophy in which forward output is maintained despite persistently elevated systemic arterial pressures and a decompensated phase in which cardiac performance has deteriorated in spite of further hypertrophic growth. To determine whether chronic antihypertensive… CONTINUE READING