Prevention of the alcohol-induced changes in brain-derived neurotrophic factor expression using neuroprotective peptides in a model of fetal alcohol syndrome.

@article{Incerti2010PreventionOT,
  title={Prevention of the alcohol-induced changes in brain-derived neurotrophic factor expression using neuroprotective peptides in a model of fetal alcohol syndrome.},
  author={Maddalena Incerti and Joy S Vink and Robin Roberson and Ines Benassou and Daniel T Abebe and Catherine Y. Spong},
  journal={American journal of obstetrics and gynecology},
  year={2010},
  volume={202 5},
  pages={457.e1-4}
}
OBJECTIVE Our objective was to evaluate whether brain-derived neurotrophic factor (BDNF) expression is affected by prenatal alcohol exposure and whether the neuroprotective effects of the vasoactive intestinal peptide (VIP)-related peptides, NAPVSIPQ (NAP) and SALLRSIPA (SAL), are mediated through BDNF. STUDY DESIGN Using a well-characterized fetal alcohol syndrome (FAS) model, timed pregnant C57BL6/J mice were treated on gestational day (E) 8 with alcohol (0.03 mL/g), placebo, or alcohol… CONTINUE READING

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Fetal lcohol spectrum disorderassociated depresion : evidence for reductions in the levels of rainderived neurotrophic factor in a mouse odel

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