Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials.

@article{Schreiber2005PreventionOS,
  title={Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials.},
  author={J. U. Schreiber and Christopher Lysakowski and Thomas Fuchs-Buder and Martin R. Tram{\`e}r},
  journal={Anesthesiology},
  year={2005},
  volume={103 4},
  pages={
          877-84
        }
}
Fifty-two randomized trials (5,318 patients) were included in this meta-analysis. In controls, the incidence of fasciculation was 95%, and the incidence of myalgia at 24 h was 50%. Nondepolarizing muscle relaxants, lidocaine, or magnesium prevented fasciculation (number needed to treat, 1.2-2.5). Best prevention of myalgia was with nonsteroidal antiinflammatory drugs (number needed to treat, 2.5) and with rocuronium or lidocaine (number needed to treat, 3). There was a dose-dependent risk of… CONTINUE READING

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