Prevention of steatosis by hepatic JNK1.

  title={Prevention of steatosis by hepatic JNK1.},
  author={Guadalupe Sabio and Julie Cavanagh-Kyros and Hwi Jin Ko and Dae Jung and Susan E Gray and John Yoonkeun Jun and Tamera Barrett and Alfonso Mora and Jason Kim and Roger J Davis},
  journal={Cell metabolism},
  volume={10 6},
Nonalcoholic steatosis (fatty liver) is a major cause of liver dysfunction that is associated with insulin resistance and metabolic syndrome. The cJun NH(2)-terminal kinase 1 (JNK1) signaling pathway is implicated in the pathogenesis of hepatic steatosis and drugs that target JNK1 may be useful for treatment of this disease. Indeed, mice with defects in JNK1 expression in adipose tissue are protected against hepatic steatosis. Here we report that mice with specific ablation of Jnk1 in… CONTINUE READING


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