Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA

@article{Boyson2011PreventionOS,
  title={Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA},
  author={Christopher O. Boyson and Tarciso Tadeu Miguel and Isabel Marian Hartmann Quadros and Joseph F. Debold and Klaus A Miczek},
  journal={Psychopharmacology},
  year={2011},
  volume={218},
  pages={257-269}
}
RationaleIntermittent exposure to social defeat stress can induce long-term neural plasticity that may influence escalated cocaine-taking behavior. Stressful encounters can lead to activation of dopamine neurons in the ventral tegmental area (VTA), which are modulated by corticotropin releasing factor (CRF) neurons.ObjectiveThe study aims to prevent the effects of intermittently scheduled, brief social defeat stress on subsequent intravenous (IV) cocaine self-administration by pretreatment with… CONTINUE READING
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