Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice.

@article{Giridharan2011PreventionOS,
  title={Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice.},
  author={Vijayasree Vayalanellore Giridharan and Rajarajan A Thandavarayan and Shinji Sato and Kam Ming Ko and Tetsuya Konishi},
  journal={Free radical research},
  year={2011},
  volume={45 8},
  pages={950-8}
}
The preventive effect of schisandrin B (Sch B), an antioxidant ingredient of Schisandra chinensis, was studied on scopolamine-induced dementia in mouse. Scopolamine developed oxidative stress in the brain with the decreased levels of antioxidant enzymes and increased nitrite level. At the same time, a significant impairment of learning and memory occurred when evaluated by passive avoidance task (PAT) and Morris water maze (MWM) with concomitant increase of acetylcholinesterase (AChE) activity… CONTINUE READING

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